Voluntary exercise modulates pathways associated with amelioration of retinal degenerative diseases.

ABSTRACT: Background: Exercise has been shown to promote a healthier and longer life and linked to a reduced risk of developing neurodegenerative diseases including retinal degenerations. However, the molecular pathways underpinning exercise-induced cellular protection are not well understood. In this work we aim to profile the molecular changes underlying exercise-induced retinal protection and investigate how exercise-induced inflammatory pathway modulation may slow the progression of retinal degenerations. Methods: Female C57Bl/6J mice at 6 weeks old were given free access to open voluntary running wheels for a period of 28 days and then subjected to 5 days of photo-oxidative damage (PD)-induced retinal degeneration. Following, retinal function (electroretinography; ERG), morphology

SUBMITTER: Chu-Tan JA 

PROVIDER: S-EPMC10036398 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature