Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges.

ABSTRACT: Diabetes and its complications cause a heavy disease burden globally. Identifying exposures, risk factors and molecular processes causally associated with the development of diabetes can provide important evidence bases for disease prevention and spur novel therapeutic strategies. Mendelian randomisation (MR), an epidemiological approach that uses genetic instruments to infer causal associations between an exposure and an outcome, can be leveraged to complement evidence from observational and clinical studies. This narrative review aims to summarise the evidence on potential causal risk factors for diabetes by integrating published MR studies on type 1 and 2 diabetes, and to reflect on future perspectives of MR studies on diabetes. Despite the genetic influence on type 1 diabetes, few MR s

SUBMITTER: Yuan S 

PROVIDER: S-EPMC10036461 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature