Characterization of radiation-resistance mechanism in Spirosoma montaniterrae DY10^T in terms of transcriptional regulatory system.

ABSTRACT: To respond to the external environmental changes for survival, bacteria regulates expression of a number of genes including transcription factors (TFs). To characterize complex biological phenomena, a biological system-level approach is necessary. Here we utilized six computational biology methods to infer regulatory network and to characterize underlying biologically mechanisms relevant to radiation-resistance. In particular, we inferred gene regulatory network (GRN) and operons of radiation-resistance bacterium Spirosoma montaniterrae DY10[Formula: see text] and identified the major regulators for radiation-resistance. Our results showed that DNA repair and reactive oxygen species (ROS) scavenging mechanisms are key processes and Crp/Fnr family transcriptional regulator works as a master

SUBMITTER: Cho C 

PROVIDER: S-EPMC10036542 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature