β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward.

ABSTRACT: β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial agents for treating both Gram-negative and Gram-positive bacterial infections. The β-lactam antibiotics, which include penicillins, cephalosporins, monobactams and carbapenems, exert their antibacterial activity by inhibiting the bacterial cell wall synthesis and have a global positive impact in treating serious bacterial infections. Today, β-lactam antibiotics are the most frequently prescribed antimicrobial across the globe. However, due to the widespread use and misapplication of β-lactam antibiotics in fields such as human medicine and animal agriculture, resistance to this superlative drug class has emerged in the majority of clinically important bacterial pathogens. This heightened antibiotic re

SUBMITTER: Narendrakumar L 

PROVIDER: S-EPMC10036598 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature