Lobar or Sublobar Resection for Peripheral Stage IA Non-Small-Cell Lung Cancer.

ABSTRACT:

Background

The increased detection of small-sized peripheral non-small-cell lung cancer (NSCLC) has renewed interest in sublobar resection in lieu of lobectomy.

Methods

We conducted a multicenter, noninferiority, phase 3 trial in which patients with NSCLC clinically staged as T1aN0 (tumor size, ≤2 cm) were randomly assigned to undergo sublobar resection or lobar resection after intraoperative confirmation of node-negative disease. The primary end point was disease-free survival, defined as the time between randomization and disease recurrence or death from any cause. Secondary end points were overall survival, locoregional and systemic recurrence, and pulmonary functions.

Results

From June 2007 through March 2017, a total of 697 patients were assigned to undergo sublo

SUBMITTER: Altorki N 

PROVIDER: S-EPMC10036605 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature