Could deep brain stimulation be a possible solution for acquired hypothalamic obesity?

ABSTRACT:

Objective

Hypothalamic dysfunction may result in morbid obesity as a consequence of decreased energy expenditure, decreased feelings of satiety, and increased fat storage. In patients with hypothalamic dysfunction, neurobehavioral dysfunction is also often present. Currently, no effective treatment has been found for hypothalamic obesity (HO). We hypothesize that deep brain stimulation (DBS) may be an effective treatment for patients with hypothalamic dysfunction, aiming to treat HO as well as the neurobehavioral dysfunction.

Methods

A systematic search was conducted in the PubMed, EMBASE and Cochrane Library databases for studies published until May 2022 reporting on DBS for the treatment of HO.

Results

Three studies met the predetermined inclusion criteria, with in

SUBMITTER: Dassen AR 

PROVIDER: S-EPMC10036662 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature