Non-canonical Wnt/Ca2+ signaling is essential to promote self-renewal and proliferation in colon cancer stem cells.

ABSTRACT:

Introduction

Cancer Stem Cells (CSC) are responsible for maintaining tumor growth, chemoresistance, and metastasis. Therefore, understanding their characteristics is critical to progress in cancer therapy. While the contribution of the canonical Wnt/b-catenin signaling in both normal and CSCs had been well established, the function of non-canonical Wnt signaling cascades in stem cells is unclear. Recently, we reported that Wnt ligands trigger complex signaling in which the canonical and non-canonical responses can be simultaneously activated by one ligand in colon cancer cells, suggesting, therefore, that noncanonical Wnt pathways may also be important in CSCs.

Methods

The present work aimed to know the role of the Wnt/Ca2+ pathway in colon CSCs. We used tumorspheres as a mo

SUBMITTER: Sarabia-Sanchez MA 

PROVIDER: S-EPMC10036746 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature