Lower diurnal HPA-axis activity in male hypertensive and coronary heart disease patients predicts future CHD risk.

ABSTRACT:

Background

Coronary heart disease (CHD) and its major risk factor hypertension have both been associated with altered activity of the hypothalamus-pituitary-adrenal (HPA)-axis but the biological mechanisms underlying prospective associations with adverse disease outcomes are unclear. We investigated diurnal HPA-axis activity in CHD-patients, hypertensive (HT) and healthy normotensive men (NT) and tested for prospective associations with biological CHD risk factors.

Methods

Eighty-three male CHD-patients, 54 HT and 54 NT men repeatedly measured salivary cortisol over two consecutive days. Prospective CHD risk was assessed by changes between baseline and follow-up in the prothrombotic factors D-dimer and fibrinogen, the pro-inflammatory measures interleukin (IL)-6, tumor necro

SUBMITTER: Degroote C 

PROVIDER: S-EPMC10036761 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature