Chronic salmon calcitonin exerts an antidepressant effect via modulating the p38 MAPK signaling pathway.

ABSTRACT: Depression is a common recurrent psychiatric disorder with a high lifetime prevalence and suicide rate. At present, although several traditional clinical drugs such as fluoxetine and ketamine, are widely used, medications with a high efficiency and reduced side effects are of urgent need. Our group has recently reported that a single administration of salmon calcitonin (sCT) could ameliorate a depressive-like phenotype via the amylin signaling pathway in a mouse model established by chronic restraint stress (CRS). However, the molecular mechanism underlying the antidepressant effect needs to be addressed. In this study, we investigated the antidepressant potential of sCT applied chronically and its underlying mechanism. In addition, using transcriptomics, we found the MAPK signaling

SUBMITTER: Zhu W 

PROVIDER: S-EPMC10036804 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature