Ginseng-based carbon dots inhibit the growth of squamous cancer cells by increasing ferroptosis.

ABSTRACT:

Background

Recent studies indicated that Ginseng potentiate cancer treatments. Ginseng-based carbon dots (GCDs) might possess properties to kill cancer cells and inhibit malignant tumor development and invasion. This study aimed to prepare GCDs, examine their effects on cancer cell growth and invasion, and explore the mechanisms involved.

Methods

GCDs were synthesized, purified, and characterized. Cells were cultured with GCDs and were tested for growth, invasiveness, and wound healing. RNA was extracted for transcriptomics analysis. Protein expression was evaluated using western blot and immunohistochemistry. Mice were injected with cancer cells and treated with PBS or GCDs. Tumor volume was evaluated.

Results

GCDs were successfully synthesized and purified. The solu

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10036825 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature