Comprehensive analysis of the biological functions of endoplasmic reticulum stress in prostate cancer.

ABSTRACT:

Introduction

Endoplasmic reticulum stress (ERS) has sizeable affect on cancer proliferation, metastasis, immunotherapy and chemoradiotherapy resistance. However, the effect of ERS on the biochemical recurrence (BCR) of prostate cancer patients remains elusive. Here, we generated an ERS-related genes risk signature to evaluate the physiological function of ERS in PCa with BCR.

Methods

We collected the ERS-related genes from the GeneCards. The edgeR package was used to screen the differential ERS-related genes in PCa from TCGA datasets. ERS-related gene risk signature was then established using LASSO and multivariate Cox regression models and validated by GEO data sets. Nomogram was developed to assess BCR-free survival possibility. Meanwhile, the correlations between ERS-rela

SUBMITTER: Cen S 

PROVIDER: S-EPMC10036859 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature