Protective effects of intrathecal injection of AAV9-RabGGTB-GFP⁺ in SOD1^G93A mice.

ABSTRACT:

Introduction

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that widely affects motor neurons of the CNS. About 20% of patients with ALS have familial ALS (fALS). One of the classic models of ALS are SOD1^G93A mice. Misfolded SOD1 protein can be overexpressed in motor neurons, which results in progressive paralysis of the limbs of mice. There is still no effective treatment for ALS. In recent years, the treatment of ALS by regulating autophagy has become a research hotspot. Autophagy obstacles have been confirmed to be one of the early pathological events of ALS. Rab7 is a member of the Ras superfamily and plays a key role in the late stage of autophagy. In our previous studies, we found that prenoylation of Rab7 was inhibited in the ALS model. Prenyla

SUBMITTER: Gao T 

PROVIDER: S-EPMC10036913 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature