A pan-cancer landscape of centromere proteins in tumorigenesis and anticancer drug sensitivity.

ABSTRACT:

Background

During mitosis and meiosis, centromere proteins (CENPs) play a key role in proper chromosome segregation. Abnormal expression of CENPs leads to chromosome instability, which is the main cause of tumorigenesis.

Methods

To elucidate the functional characteristics of CENPs in pan-cancer, we comprehensively analyzed the expression landscape of CENPs and their relationships with patient survival, genomic alterations, tumor immunity, tumor microenvironment, and anticancer drug sensitivity. The expression patterns and signaling pathways of CENPs were identified through multiple bioinformatics mining and experimental verification. GEPIA2 and PrognoScan were implemented to evaluate the prognostic value of CENPs. The molecular functions of CENPs in pan-cancer were comprehen

SUBMITTER: Shi YX 

PROVIDER: S-EPMC10036944 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature