Prevalence, association, and prognostic significance of polypharmacy and sarcopenia in patients with liver cirrhosis.

ABSTRACT:

Background and aim

Polypharmacy and sarcopenia are increasing public health problems worldwide. However, data on the prevalence, association, and prognostic significance of polypharmacy and sarcopenia in patients with liver cirrhosis are limited.

Methods

Polypharmacy and sarcopenia were assessed in 239 patients with liver cirrhosis. Polypharmacy was defined as the daily use of six or more medications, and sarcopenia was diagnosed based on muscle strength and mass evaluated on computed tomography. The association between polypharmacy and sarcopenia and their effects on mortality were analyzed using logistic regression and Cox proportional hazards models.

Results

Among the 239 patients, 52% were men, the median age was 68 years, and the number of medications used per pa

SUBMITTER: Hanai T 

PROVIDER: S-EPMC10037035 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature