Next-generation humanized NSG-SGM3 mice are highly susceptible to Staphylococcus aureus infection.

ABSTRACT: Humanized hemato-lymphoid system mice, or humanized mice, emerged in recent years as a promising model to study the course of infection of human-adapted or human-specific pathogens. Though Staphylococcus aureus infects and colonizes a variety of species, it has nonetheless become one of the most successful human pathogens of our time with a wide armory of human-adapted virulence factors. Humanized mice showed increased vulnerability to S. aureus compared to wild type mice in a variety of clinically relevant disease models. Most of these studies employed humanized NSG (NOD-scid IL2Rg^null) mice which are widely used in the scientific community, but show poor human myeloid cell reconstitution. Since this immune cell compartment plays a decisive role in the defe

SUBMITTER: Hung S 

PROVIDER: S-EPMC10037040 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature