Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV.

ABSTRACT:

Background

Mechanisms contributing to COVID-19 severity in people with HIV (PWH) are poorly understood. We evaluated temporal changes in plasma proteins following SARS-CoV-2 infection and identified pre-infection proteomic markers associated with future COVID-19.

Methods

We leveraged data from the global Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE). Antiretroviral therapy (ART)-treated PWH with clinical, antibody-confirmed COVID-19 as of September 2021 were matched on geographic region, age, and sample timing to antibody negative controls. For cases and controls, pre COVID-19 pandemic specimens were obtained prior to January 2020 to assess change over time and relationship to COVID-19 severity, using false-discovery adjusted mixed effects modeling.

Findin

SUBMITTER: Kolossvary M 

PROVIDER: S-EPMC10037041 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature