Qingfei Jiedu Granules fight influenza by regulating inflammation, immunity, metabolism, and gut microbiota.

ABSTRACT:

Background and aim

Qingfei Jiedu Granules (QFJD) are a new Traditional Chinese Medicine (TCM) which has been clinically used against coronavirus pneumonia in China. In this study, the therapeutic effect and the underlying mechanisms of QFJD against influenza were investigated.

Experimental procedure

Pneumonia mice were induced by influenza A virus. Survival rate, weight loss, lung index and lung pathology were measured to evaluate the therapeutic effect of QFJD. The expression of inflammatory factors and lymphocytes was used to assess anti-inflammatory and immunomodulatory effect of QFJD. Gut microbiome analysis was performed to decipher the potential effect of QFJD on intestinal microbiota. Metabolomics approach was conducted to explore the overall metabolic regulation of Q

SUBMITTER: Cui X 

PROVIDER: S-EPMC10037062 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature