Self-assembled GA-Repeated Peptides as a Biomolecular Scaffold for Biosensing with MoS₂ Electrochemical Transistors.

ABSTRACT: Biosensors with two-dimensional materials have gained wide interest due to their high sensitivity. Among them, single-layer MoS₂ has become a new class of biosensing platform owing to its semiconducting property. Immobilization of bioprobes directly onto the MoS₂ surface with chemical bonding or random physisorption has been widely studied. However, these approaches potentially cause a reduction of conductivity and sensitivity of the biosensor. In this work, we designed peptides that spontaneously align into monomolecular-thick nanostructures on electrochemical MoS₂ transistors in a non-covalent fashion and act as a biomolecular scaffold for efficient biosensing. These peptides consist of repeated domains of glycine and alanine in the sequence and form self

SUBMITTER: Noguchi H 

PROVIDER: S-EPMC10037235 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature