Cellular Contact Guidance on Liquid Crystalline Networks with Anisotropic Roughness.

ABSTRACT: Cell contact guidance is widely employed to manipulate cell alignment and differentiation in vitro. The use of nano- or micro-patterned substrates allows efficient control of cell organization, thus opening up to biological models that cannot be reproduced spontaneously on standard culture dishes. In this paper, we explore the concept of cell contact guidance by Liquid Crystalline Networks (LCNs) presenting different surface topographies obtained by self-assembly of the monomeric mixture. The materials are prepared by photopolymerization of a low amount of diacrylate monomer dissolved in a liquid crystalline solvent, not participating in the reaction. The alignment of the liquid crystals, obtained before polymerization, determines the scaffold morphology, characterized by a nanometr

SUBMITTER: Rojas-Rodriguez M 

PROVIDER: S-EPMC10037237 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature