3D Graphene Oxide-Polyethylenimine Scaffolds for Cardiac Tissue Engineering.

ABSTRACT: The development of novel three-dimensional (3D) nanomaterials combining high biocompatibility, precise mechanical characteristics, electrical conductivity, and controlled pore size to enable cell and nutrient permeation is highly sought after for cardiac tissue engineering applications including repair of damaged heart tissues following myocardial infarction and heart failure. Such unique characteristics can collectively be found in hybrid, highly porous tridimensional scaffolds based on chemically functionalized graphene oxide (GO). By exploiting the rich reactivity of the GO's basal epoxydic and edge carboxylate moieties when interacting, respectively, with NH₂ and NH₃⁺ groups of linear polyethylenimines (PEIs), 3D architectures with variable thickness an

SUBMITTER: Pilato S 

PROVIDER: S-EPMC10037243 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature