Precision medicine in inflammatory bowel disease: Individualizing the use of biologics and small molecule therapies.

ABSTRACT: The advent of biologics and small molecules in inflammatory bowel disease (IBD) has marked a significant turning point in the prognosis of IBD, decreasing the rates of corticosteroid dependence, hospitalizations and improving overall quality of life. The introduction of biosimilars has also increased affordability and enhanced access to these otherwise costly targeted therapies. Biologics do not yet represent a complete panacea: A subset of patients do not respond to first-line anti-tumor necrosis factor (TNF)-alpha agents or may subsequently demonstrate a secondary loss of response. Patients who fail to respond to anti-TNF agents typically have a poorer response rate to second-line biologics. It is uncertain which patient would benefit from a different sequencing of biologics or even a co

SUBMITTER: Cheah E 

PROVIDER: S-EPMC10037250 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature