Li vs Na: Divergent Reaction Patterns between Organolithium and Organosodium Complexes and Ligand-Catalyzed Ketone/Aldehyde Methylenation.

ABSTRACT: Organosodium chemistry is underdeveloped compared with organolithium chemistry, and all the reported organosodium complexes exhibit similar, if not identical, reactivity patterns to their lithium counterparts. Herein, we report a rare organosodium monomeric complex, namely, [Na(CH₂SiMe₃)(Me₆Tren)] (1-Na) (Me₆Tren: tris[2-(dimethylamino)ethyl]amine) stabilized by a tetra-dentate neutral amine ligand Me₆Tren. Employing organo-carbonyl substrates (ketones, aldehydes, amides, ester), we demonstrated that 1-Na features distinct reactivity patterns compared with its lithium counterpart, [Li(CH₂SiMe₃)(Me₆Tren)] (1-Li). Based on this knowledge, we further developed a ligand-catalysis

SUBMITTER: Davison N 

PROVIDER: S-EPMC10037334 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature