Construction and validation of a multi-epitope in silico vaccine model for lymphatic filariasis by targeting Brugia malayi: a reverse vaccinology approach.

ABSTRACT:

Background

Lymphatic filariasis (LF), often referred to as elephantiasis, has been identified as one of the 17 neglected tropical diseases by the World Health Organization. Currently, there are no vaccines available to treat this infection in humans. Therefore, with the objective of devising a novel preventive measure, we exploited an immunoinformatics approach to design a multi-epitope-based subunit vaccine for LF, that can elicit a variety of immune responses within the host. In this study, different B cell, T_C cell, and T_H cell-binding epitopes were screened from the antigenic proteins of Brugia malayi and they were passed through several immunological filters to determine the optimal epitopes.

Results

As a result, 15 CD8+, 3 CD4+, and 3 B cel

SUBMITTER: Madanagopal P 

PROVIDER: S-EPMC10037386 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature