Association of a variant upstream of growth differentiation factor 11 (GDF11) on carcass traits in crossbred beef cattle.

ABSTRACT: The mature peptide of growth differentiation factor 11 (GDF11) in Bos taurus breeds, shares 90% amino acid sequence similarity to myostatin (MSTN), where loss-of-function mutations result in muscular hyperplasia causing a phenotype known as double-muscling. Mutations in the MSTN coding sequence increase muscle mass and reduce fat and bone tissues, but also confer poor fertility, reduced stress tolerance, and increased calf mortality. GDF11 influences skeletal muscle development in mice, and muscular atrophy can be induced by exogenous GDF11 treatment. To date, there are no reports of GDF11's role in bovine carcass traits. To determine associations between GDF11 and carcass quality in beef cattle, bovine GDF11 was examined in crossbred Canadian beef cattle populations during finishin

SUBMITTER: Spencer RJ 

PROVIDER: S-EPMC10037423 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature