Modular Chemical Construction of IgG-like Mono- and Bispecific Synthetic Antibodies (SynAbs).

ABSTRACT: In recent years there has been rising interest in the field of protein-protein conjugation, especially related to bispecific antibodies (bsAbs) and their therapeutic applications. These constructs contain two paratopes capable of binding two distinct epitopes on target molecules and are thus able to perform complex biological functions (mechanisms of action) not available to monospecific mAbs. Traditionally these bsAbs have been constructed through protein engineering, but recently chemical methods for their construction have started to (re)emerge. While these have been shown to offer increased modularity, speed, and for some methods even the inherent capacity for further functionalization (e.g., with small molecule cargo), most of these approaches lacked the ability to include a fragment

SUBMITTER: Thoreau F 

PROVIDER: S-EPMC10037451 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature