Augmenter of Liver Regeneration Monoclonal Antibody Promotes Apoptosis of Hepatocellular Carcinoma Cells.

ABSTRACT:

Background and aims

Hepatocellular carcinoma (HCC) is one of the most common types of cancer, often resulting in death. Augmenter of liver regeneration (ALR), a widely expressed multifunctional protein, has roles in liver disease. In our previous study, we reported that ALR knockdown inhibited cell proliferation and promoted cell death. However, there is no study on the roles of ALR in HCC.

Methods

We used in vitro and in vivo models to investigate the effects of ALR in HCC as well as its mechanism of action. We produced and characterized a human ALR-specific monoclonal antibody (mAb) and investigated the effects of the mAb in HCC cells.

Results

The purified ALR-specific mAb matched the predicted molecular weight of IgG heavy and light chains. Thereafter

SUBMITTER: Huang LL 

PROVIDER: S-EPMC10037511 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature