Fas/FasL and Complement Activation are Associated with Chronic Active Epstein-Barr Virus Hepatitis.

ABSTRACT:

Background and aims

Chronic active Epstein-Barr virus hepatitis (CAEBVH) is a rare and highly lethal disease characterized by hepatitis and hepatomegaly. This study aimed to investigate the clinicopathological features and pathogenic mechanisms of CAEBVH.

Methods

Ten patients with confirmed Epstein-Barr virus hepatitis infection were enrolled. The clinicopathological characteristics of these patients were summarized and analyzed. Flow cytometry was utilized to detect peripheral blood immune cell phenotypes and whole exome sequencing was used to explore pathogenic genetic mechanisms. Lastly, immunohistochemical staining was employed to verify pathogenic mechanisms.

Results

Clinical features observed in all Epstein-Barr virus hepatitis patients included fever (7/10), sp

SUBMITTER: Lin J 

PROVIDER: S-EPMC10037519 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature