Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials.

ABSTRACT: The availability of high-fidelity animal models for oncology research has grown enormously in recent years, enabling preclinical studies relevant to prevention, diagnosis, and treatment of cancer to be undertaken. This has led to increased opportunities to conduct co-clinical trials, which are studies on patients that are carried out parallel to or sequentially with animal models of cancer that mirror the biology of the patients' tumors. Patient-derived xenografts (PDX) and genetically engineered mouse models (GEMM) are considered to be the models that best represent human disease and have high translational value. Notably, one element of co-clinical trials that still needs significant optimization is quantitative imaging. The National Cancer Institute has organized a Co-Clinical Imaging R

SUBMITTER: Peehl DM 

PROVIDER: S-EPMC10037611 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature