Intraocular Methotrexate for the Treatment and Prevention of Proliferative Vitreoretinopathy: A Review.

ABSTRACT:

Purpose

To review the current literature on the use of intravitreal methotrexate (IVT MTX) for the treatment and prevention of proliferative vitreoretinopathy (PVR).

Methods

All reports of IVT MTX to treat and prevent PVR published in PubMed, Google Scholar, and EBSCOhost were reviewed. The relevant current studies are included in this report.

Results

The literature search yielded 32 articles describing the use of MTX in PVR. These included preclinical studies, 1 case report, and several case series. Early studies found that IVT MTX is a promising medication for the treatment and prevention of PVR. MTX works as a potent anti-inflammatory agent through a new mechanism of action different from that of other medications for use in PVR. Few side effects have been reported

SUBMITTER: McAllister MA 

PROVIDER: S-EPMC10037751 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature