Intense solar activity reduces urinary 6-sulfatoxymelatonin in patients with COPD.

ABSTRACT:

Background

Little is known about the link between solar activity and variations in melatonin. In this study, we investigated if melatonin's major urinary metabolite, urinary 6-sulfatoxymelatonin (aMT6s), is lowest under periods of intense solar activity.

Methods

We investigated associations between high-energy solar particle events [Coronal Mass Ejection (CME) mass, speed and energy] on creatinine-adjusted aMT6s (aMT6sr) concentrations in 140 patients with chronic obstructive pulmonary disease (COPD) using up to four seasonal urine samples (n = 440). Mixed effect models with a random intercept for each subject were used to estimate associations, including effect modification attributable to diabetes, obesity, and reduced pulmonary function.

Results

Higher values of CM

SUBMITTER: Zilli Vieira CL 

PROVIDER: S-EPMC10037776 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature