Gut dysbiosis is associated with aortic aneurysm formation and progression in Takayasu arteritis.

ABSTRACT:

Background

Takayasu arteritis (TAK) is an autoimmune large vessel vasculitis that affects the aorta and its major branches, eventually leading to the development of aortic aneurysm and vascular stenosis or occlusion. This retrospective and prospective study aimed to investigate whether the gut dysbiosis exists in patients with TAK and to identify specific gut microorganisms related to aortic aneurysm formation/progression in TAK.

Methods

We analysed the faecal microbiome of 76 patients with TAK and 56 healthy controls (HCs) using 16S ribosomal RNA sequencing. We examined the relationship between the composition of the gut microbiota and clinical parameters.

Results

The patients with TAK showed an altered gut microbiota with a higher abundance of oral-derived bacteria,

SUBMITTER: Manabe Y 

PROVIDER: S-EPMC10037851 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature