Protective role of FBXL19 in Streptococcus pneumoniae-induced lung injury in pneumonia immature mice.

ABSTRACT:

Objective

Streptococcus pneumoniae (Spn) is a common pathogen for pediatric pneumonia and leads to severe lung injury. This study is conducted to analyze the role of F-box and leucine rich repeat protein 19 (FBXL19) in Spn-induced lung injury in immature mice.

Methods

Immature mice were infected with Spn to record the survival rates and bacterial loads in bronchoalveolar lavage fluid. Levels of FBXL19 and FOXM1 in lung tissues were determined via real-time quantitative polymerase chain reaction or Western blotting. After the interference of FBXL19, its impacts on lung inflammatory injury were appraised by the lung wet/dry weight ratio, myeloperoxidase activity, hematoxylin and eosin staining, and enzyme-linked immunosorbent assay. The binding of FBXL19 to forkhead box M1 (FO

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10037874 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature