SERPINE1 and its co-expressed genes are associated with the progression of clear cell renal cell carcinoma.

ABSTRACT:

Background

Clear cell renal cell carcinoma(ccRCC) is a frequently occurring malignant tumor of the urinary system. Despite extensive research, the regulatory mechanisms underlying the pathogenesis and progression of ccRCC remain largely unknown.

Methods

We downloaded 5 ccRCC expression profiles from the Gene Expression Omnibus (GEO) database and obtained the list of differentially expressed genes (DEGs). Using String and Cytoscape tools, we determined the hub genes of ccRCC, and then analyzed their relationship with ccRCC patient survival. Ultimately, we identified SERPINE1 as a prognostic factor in ccRCC. Meanwhile, we confirmed the role of SERPINE1 in 786-O cells by cell transfection and in vitro experiments.

Results

Our analysis yielded a total of 258 differentiall

SUBMITTER: Guo L 

PROVIDER: S-EPMC10037920 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature