Gut microbiota modulates visceral sensitivity through calcitonin gene-related peptide (CGRP) production.

ABSTRACT: Abdominal pain is common in patients with gastrointestinal disorders, but its pathophysiology is unclear, in part due to poor understanding of basic mechanisms underlying visceral sensitivity. Accumulating evidence suggests that gut microbiota is an important determinant of visceral sensitivity. Clinical and basic research studies also show that sex plays a role in pain perception, although the precise pathways are not elucidated. We investigated pain responses in germ-free and conventionally raised mice of both sexes, and assessed visceral sensitivity to colorectal distension, neuronal excitability of dorsal root ganglia (DRG) neurons and the production of substance P and calcitonin gene-related peptide (CGRP) in response to capsaicin or a mixture of G-protein coupled receptor (GPCR) agon

SUBMITTER: Pujo J 

PROVIDER: S-EPMC10038053 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature