Establishing cognitive baseline in three generations: Framingham Heart Study.

ABSTRACT:

Introduction

Generational changes warrant recalibrating normative cognitive measures to detect changes indicative of dementia risk within each generation.

Methods

We performed linear regressions to compare eight neuropsychological (NP) tests among three-generation cohorts at baseline in Framingham Heart Study (FHS, n = 4787) and conducted Cox regressions to investigate the relationships of NP tests with generation-specific dementia risk.

Results

The FHS second and third generations performed better than the first generation for seven NP tests (0.14-0.81 standard deviation improvement, P ≤ .001) while the second and third generations performed similarly for six of eight NP tests (P > .05). One standard deviation better performance was associated wi

SUBMITTER: Yang J 

PROVIDER: S-EPMC10038074 | biostudies-literature | 2023 Jan-Mar

REPOSITORIES: biostudies-literature