Identifying effects of genetic obesity exposure on leukocyte telomere length using Mendelian randomization.

ABSTRACT:

Background

Observational studies have shown that obesity is closely associated with leukocyte telomere length (LTL). However, the causal relationship between obesity and LTL remains unclear. This study investigated the causal relationship between obesity and LTL through the Mendelian randomization approach.

Materials and methods

The genome-wide association study (GWAS) summary data of several studies on obesity-related traits with a sample size of more than 600,000 individuals were extracted from the UK Biobank cohort. The summary-level data of LTL-related GWAS (45 6,717 individuals) was obtained from the IEU Open GWAS database. An inverse-variance-weighted (IVW) algorithm was utilized as the primary MR analysis method. Sensitivity analyses were conducted via MR-Egger

SUBMITTER: Wan B 

PROVIDER: S-EPMC10038084 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature