Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine.

ABSTRACT: Advances in antigen targeting in veterinary medicine have gained traction over the years as an alternative approach for diseases that remain a challenge for traditional vaccines. In addition to the nature of the immunogen, antigen-targeting success relies heavily on the chosen receptor for its direct influence on the elicited response that will ensue after antigen uptake. Different approaches using antibodies, natural or synthetic ligands, fused proteins, and DNA vaccines have been explored in various veterinary species, with pigs, cattle, sheep, and poultry as the most frequent models. Antigen-presenting cells can be targeted using a generic approach, such as broadly expressed receptors such as MHC-II, CD80/86, CD40, CD83, etc., or focused on specific cell populations such as dendritic ce

SUBMITTER: Melgoza-Gonzalez EA 

PROVIDER: S-EPMC10038197 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature