Genetically predicted levels of folate, vitamin B₁₂, and risk of autoimmune diseases: A Mendelian randomization study.

ABSTRACT:

Background

Evidence from observational studies on the association of folate and vitamin B₁₂ with autoimmune diseases are conflicting.

Objective

We aimed to investigate the relationship of folate and vitamin B₁₂ with autoimmune diseases using Mendelian randomization (MR).

Materials and methods

We selected single-nucleotide polymorphisms associated with folate and vitamin B₁₂ at the genome-wide significance level. Summary-level data for four common autoimmune diseases (vitiligo, inflammatory bowel disease, rheumatoid arthritis, and systemic lupus erythematosus) were obtained from large-scale genome-wide association studies, with a sample size of 44,266, 86,640, 58,284, and 23,210, respectively. MR analyses were conducted using the invers

SUBMITTER: Yang H 

PROVIDER: S-EPMC10038229 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature