PSMD11 modulates circadian clock function through PER and CRY nuclear translocation.

ABSTRACT: The molecular circadian clock is regulated by a transcriptional translational feedback loop. However, the post-translational control mechanisms are less understood. The NRON complex is a large ribonucleoprotein complex, consisting of a lncRNA and several proteins. Components of the complex play a distinct role in regulating protein phosphorylation, synthesis, stability, and translocation in cellular processes. This includes the NFAT and the circadian clock pathway. PSMD11 is a component of the NRON complex and a lid component of the 26S proteasome. Among the PSMD family members, PSMD11 has a more specific role in circadian clock function. Here, we used cell and biochemical approaches and characterized the role of PSMD11 in regulating the stability and nuclear translocation of circadian clo

SUBMITTER: Cal-Kayitmazbatir S 

PROVIDER: S-EPMC10038281 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature