Characterizing White Matter Tract Degeneration in Syndromic Variants of Alzheimer's Disease: A Diffusion Tensor Imaging Study.

ABSTRACT:

Background

Different clinical syndromes can arise from Alzheimer's disease (AD) neuropathology, including dementia of the Alzheimer's type (DAT), logopenic primary progressive aphasia (lvPPA), and posterior cortical atrophy (PCA).

Objective

To assess similarities and differences in patterns of white matter tract degeneration across these syndromic variants of AD.

Methods

Sixty-four subjects (22 DAT, 24 lvPPA, and 18 PCA) that had diffusion tensor imaging and showed amyloid-β deposition on PET were assessed in this case-control study. A whole-brain voxel-based analysis was performed to assess differences in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity across groups.

Results

All three groups showed overlapping diffusion abnor

SUBMITTER: Madhavan A 

PROVIDER: S-EPMC10038690 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature