Vascular Normalization Was Associated with Colorectal Tumor Regression upon Anti-PD-L1 Combinational Therapy.

ABSTRACT: Anti-PD-L1 therapy exhibits durable efficacy, but only in a small fraction of cancer patients. The immunosuppressive tumor microenvironment (TME) is a crucial obstacle that impedes cancer immunotherapy. Here, we found that anti-PD-L1 therapy coupled with CD4⁺ T cell depletion induced colorectal tumor regression and vascular normalization, while monotherapy only retarded tumor growth without affecting the tumor vasculature. Moreover, simultaneous PD-L1 blockade and CD4⁺ T cell depletion eradicated intratumoral PD-L1⁺ lymphoid and myeloid cell populations, while additively elevating the proportions of CD44⁺CD69⁺CD8⁺, central memory CD44⁺CD62L⁺CD8⁺, and effector memory CD44⁺CD62L

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10038742 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature