Periconceptional antibiotic use and spontaneous abortion: A prospective cohort study.

ABSTRACT:

Background

Many reproductive-aged North Americans use antibiotics in the weeks preceding conception or during early pregnancy. Antibiotic use may influence risk of spontaneous abortion (SAB) by disrupting the reproductive tract microbiome or treating harmful infections. However, this association has not been extensively studied.

Objective

To determine the extent to which periconceptional antibiotic use is associated with the risk of SAB.

Methods

We analysed data from an internet-based preconception cohort study of pregnancy planners. Eligible participants self-identified as female, were aged 21-45 years, resided in the USA or Canada, and conceived during 12 months of follow-up (n = 7890). Participants completed an enrolment questionnaire during June 2013-September 202

SUBMITTER: Crowe HM 

PROVIDER: S-EPMC10038811 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature