Effectiveness research in oncology with electronic health record data: A retrospective cohort study emulating the PALOMA-2 trial.

ABSTRACT:

Purpose

Oncology electronic health record (EHR) databases have increased in quality and availability over the past decade, yet it remains unclear whether these clinical practice data can be used to conduct reliable comparative effectiveness studies. We sought to emulate a clinical trial with EHR data in the advanced breast cancer population and compare our results against the trial.

Methods

This cohort study used EHR data from US oncology practices. All elements of the study were defined to mimic the PALOMA-2 trial as closely as possible. Patients with hormone-positive, HER-2 negative metastatic breast cancer with no prior treatment for metastatic disease were included. Patients initiating palbociclib and letrozole on the same day following the earliest record of metastasis

SUBMITTER: Merola D 

PROVIDER: S-EPMC10038825 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature