Inhibition of NLRP3 inflammasome activity by MCC950 leads to exacerbation of Sjоgren's syndrome pathologies in non-obese diabetic mice.

ABSTRACT: Sjӧgren's syndrome (SS) is an autoimmune inflammatory disease characterized by chronic inflammation and dysfunction of exocrine glands and causes dry mouth, dry eyes and various systemic health problems. The objective of this study is to define the in vivo actions of the endogenous NLRP3 inflammasome, a key initiator and mediator of various immune and inflammatory conditions, in newly established SS disease. MCC950, a highly specific small-molecule inhibitor of NLRP3 inflammasome formation and activation, was intraperitoneally administered to the female non-obese diabetic (NOD) mice aged 11 weeks, which have newly established SS-like hyposalivation and pathologies. The injection was conducted three times weekly for three consecutive weeks and mice were analysed for characteristic SS pathol

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10038882 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature