Rare genetic variants correlate with better processing speed.

ABSTRACT: We conducted a genome-wide association study of Digit Symbol Substitution Test scores administered in 4207 family members of the Long Life Family Study (LLFS). Genotype data were imputed to the HRC panel of 64,940 haplotypes resulting in ∼15M genetic variants with a quality score > 0.7. The results were replicated using genetic data imputed to the 1000 Genomes phase 3 reference panel from 2 Danish twin cohorts: the study of Middle Aged Danish Twins and the Longitudinal Study of Aging Danish Twins. The genome-wide association study in LLFS discovered 18 rare genetic variants (minor allele frequency (MAF) < 1.0%) that reached genome-wide significance (p-value < 5 × 10^-8). Among these, 17 rare variants in chromosome 3 had large protective effects on the processing speed, including

SUBMITTER: Song Z 

PROVIDER: S-EPMC10038891 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature