F4/80⁺Ly6C^high Macrophages Lead to Cell Plasticity and Cancer Initiation in Colitis.

ABSTRACT:

Background & aims

Colorectal cancer is a leading cause of cancer death, and a major risk factor is chronic inflammation. Despite the link between colitis and cancer, the mechanism by which inflammation leads to colorectal cancer is not well understood.

Methods

To investigate whether different forms of inflammation pose the same risk of cancer, we compared several murine models of colitis (dextran sodium sulfate [DSS], 2,4,6-trinitrobenzene sulfonic acid, 4-ethoxylmethylene-2-phenyloxazol-5-one, Citrobacter rodentium, Fusobacterium nucleatum, and doxorubicin) with respect to their ability to lead to colonic tumorigenesis. We attempted to correlate the severity of colitis and inflammatory profile with the risk of tumorigenesis in both azoxymethane-dependent and Dclk1/APC^f

SUBMITTER: Shin AE 

PROVIDER: S-EPMC10038892 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature