IL-1/MyD88-Dependent G-CSF and IL-6 Secretion Mediates Postburn Anemia.

ABSTRACT: The anemia of critical illness (ACI) is a nearly universal pathophysiological consequence of burn injury and a primary reason burn patients require massive quantities of transfused blood. Inflammatory processes are expected to drive postburn ACI and prevent meaningful erythropoietic stimulation through iron or erythropoietin supplementation, but to this day no specific inflammatory pathways have been identified as a critical mechanism. In this study, we examined whether secretion of G-CSF and IL-6 mediates distinct features of postburn ACI and interrogated inflammatory mechanisms that could be responsible for their secretion. Our analysis of mouse and human skin samples identified the burn wound as a primary source of G-CSF and IL-6 secretion. We show that G-CSF and IL-6 are secreted indep

SUBMITTER: Noel JG 

PROVIDER: S-EPMC10038902 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature