Aberrations in the early pregnancy serum metabolic profile in women with prediabetes at two years postpartum.

ABSTRACT:

Introduction

Aberrations in circulating metabolites have been associated with diabetes and cardiovascular risk.

Objectives

To investigate if early and late pregnancy serum metabolomic profiles differ in women who develop prediabetes by two years postpartum compared to those who remain normoglycemic.

Methods

An NMR metabolomics platform was used to measure 228 serum metabolite variables from women with pre-pregnancy overweight in early and late pregnancy. Co-abundant groups of metabolites were compared between the women who were (n = 40) or were not (n = 138) prediabetic at two years postpartum. Random Forests classifiers, based on the metabolic profiles, were used to predict the prediabetes status, and correlations of the metabolites to glycemic traits (fasting glucos

SUBMITTER: Muhli E 

PROVIDER: S-EPMC10038958 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature