Transmembrane signaling by a synthetic receptor in artificial cells.

ABSTRACT: Signal transduction across biological membranes is among the most important evolutionary achievements. Herein, for the design of artificial cells, we engineer fully synthetic receptors with the capacity of transmembrane signaling, using tools of chemistry. Our receptors exhibit similarity with their natural counterparts in having an exofacial ligand for signal capture, being membrane anchored, and featuring a releasable messenger molecule that performs enzyme activation as a downstream signaling event. The main difference from natural receptors is the mechanism of signal transduction, which is achieved using a self-immolative linker. The receptor scaffold is modular and can readily be re-designed to respond to diverse activation signals including biological or chemical stimuli. We demonstr

SUBMITTER: Sogaard AB 

PROVIDER: S-EPMC10039019 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature