Curvature induces active velocity waves in rotating spherical tissues.

ABSTRACT: The multicellular organization of diverse systems, including embryos, intestines, and tumors relies on coordinated cell migration in curved environments. In these settings, cells establish supracellular patterns of motion, including collective rotation and invasion. While such collective modes have been studied extensively in flat systems, the consequences of geometrical and topological constraints on collective migration in curved systems are largely unknown. Here, we discover a collective mode of cell migration in rotating spherical tissues manifesting as a propagating single-wavelength velocity wave. This wave is accompanied by an apparently incompressible supracellular flow pattern featuring topological defects as dictated by the spherical topology. Using a minimal active particle mode

SUBMITTER: Brandstatter T 

PROVIDER: S-EPMC10039078 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature